Recent Publication: Enhanced Mixture Separations of Metal Adducted Tetrasaccharides

morrisonftimstetras

Using a combination of Fourier transform ion mobility and ion trap mass spectrometry Kelsey demonstrated the degree to which different metal cations were able to enhance isomer separations across a set of tetrasaccharides.  While full resolution was not achieved for the full set of 5 isomers this work demonstrates the current state of the art for true isomeric mixture separations using IMS.  Another interesting aspect of this work was the observation of metal cation bound dimers.  Though we couldn’t tell whether they were homo or heterodimers we’ve now obtained a deuterated set of isomers which will help to answer that question.

Paper Link: http://link.springer.com/article/10.1007/s13361-016-1505-y

 

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