{"id":607,"date":"2018-05-31T21:38:41","date_gmt":"2018-05-31T21:38:41","guid":{"rendered":"http:\/\/www.clowersresearch.com\/main\/?p=607"},"modified":"2018-05-31T22:10:09","modified_gmt":"2018-05-31T22:10:09","slug":"im-ms-assessment-of-cobalt-glycan-heterodimers","status":"publish","type":"post","link":"http:\/\/www.clowersresearch.com\/main\/im-ms-assessment-of-cobalt-glycan-heterodimers\/","title":{"rendered":"IM-MS Assessment of Cobalt-Glycan Heterodimers"},"content":{"rendered":"\n\t\t<style type=\"text\/css\">\n\t\t\t#gallery-1 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-1 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 100%;\n\t\t\t}\n\t\t\t#gallery-1 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-1 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-1' class='gallery galleryid-607 gallery-columns-1 gallery-size-large'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='http:\/\/www.clowersresearch.com\/main\/im-ms-assessment-of-cobalt-glycan-heterodimers\/figure4_v2-2\/'><img width=\"1024\" height=\"587\" src=\"http:\/\/www.clowersresearch.com\/main\/wp-content\/uploads\/2018\/05\/Figure4_v2-1024x587.jpg\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"http:\/\/www.clowersresearch.com\/main\/wp-content\/uploads\/2018\/05\/Figure4_v2-1024x587.jpg 1024w, http:\/\/www.clowersresearch.com\/main\/wp-content\/uploads\/2018\/05\/Figure4_v2-300x172.jpg 300w, http:\/\/www.clowersresearch.com\/main\/wp-content\/uploads\/2018\/05\/Figure4_v2-768x440.jpg 768w, http:\/\/www.clowersresearch.com\/main\/wp-content\/uploads\/2018\/05\/Figure4_v2-250x143.jpg 250w, http:\/\/www.clowersresearch.com\/main\/wp-content\/uploads\/2018\/05\/Figure4_v2-150x86.jpg 150w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/dt><\/dl><br style=\"clear: both\" \/>\n\t\t<\/div>\n\n<p>Continuing along our previous work to characterize certain cationized glycans <a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs13361-016-1505-y\">with a variety of metals<\/a> and <a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs13361-017-1621-3\">with cobalt to enhance UV photon absorption<\/a>, we are pleased to show our effort to demonstrate the formation of heterodimeric cobalt-glycan adducts in published form. Now appearing as an online-first article in <em>Journal of the American Society for Mass Spectrometry<\/em>, our paper &#8220;<a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs13361-018-1982-2\">Assessment of Dimeric Metal-Glycan Adducts via Isotopic Labeling and Ion Mobility-Mass Spectrometry<\/a>&#8221; presents how important ion mobility separations are for tandem MS experiments performed on divalent metal-glycan adducts. Without the ability to use drift times to distinguish which precursor produced which fragment ions, component fragments from a heterodimeric adduct of two isomers cannot be deconvoluted. Specifically, the potential for isomers to form doubly-charged heterodimers&#8211;that are then dissociated into component fragments&#8211;will essentially create a scenario where chimeric fragmentation spectra are produced.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Continuing along our previous work to characterize certain cationized glycans with a variety of metals and with cobalt to enhance UV photon absorption, we are pleased to show our effort to demonstrate the formation of heterodimeric cobalt-glycan adducts in published form. Now appearing as an online-first article in Journal of the American Society for Mass [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":608,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"spay_email":""},"categories":[12,22],"tags":[],"jetpack_featured_media_url":"http:\/\/www.clowersresearch.com\/main\/wp-content\/uploads\/2018\/05\/TOC_v2_4-pdf.jpg","_links":{"self":[{"href":"http:\/\/www.clowersresearch.com\/main\/wp-json\/wp\/v2\/posts\/607"}],"collection":[{"href":"http:\/\/www.clowersresearch.com\/main\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.clowersresearch.com\/main\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.clowersresearch.com\/main\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.clowersresearch.com\/main\/wp-json\/wp\/v2\/comments?post=607"}],"version-history":[{"count":6,"href":"http:\/\/www.clowersresearch.com\/main\/wp-json\/wp\/v2\/posts\/607\/revisions"}],"predecessor-version":[{"id":621,"href":"http:\/\/www.clowersresearch.com\/main\/wp-json\/wp\/v2\/posts\/607\/revisions\/621"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.clowersresearch.com\/main\/wp-json\/wp\/v2\/media\/608"}],"wp:attachment":[{"href":"http:\/\/www.clowersresearch.com\/main\/wp-json\/wp\/v2\/media?parent=607"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.clowersresearch.com\/main\/wp-json\/wp\/v2\/categories?post=607"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.clowersresearch.com\/main\/wp-json\/wp\/v2\/tags?post=607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}