News

  • Congrats to Zhihao Yu for a successful dissertation defense! Congrats to Zhihao Yu for a successful dissertation defense!
  • Updated IMS Worksheet — 2018 For those that are interested, here is the spreadsheet used in the ASMS 2018 short course.  Thank Dr. Bill Siems if you see him.   Ion Mobility Cal v3
  • Ambient Alkylphosphonic Acid Vapor Detection and Ion Traps Atmospheric flow tube-mass spectrometry (AFT-MS) first emerged in 2012 as an ambient vapor sampling technique developed by Ewing et al. and applied to the sensing of trace quantities of RDX molecules clustered with nitrate ions. This iteration of AFT-MS used selected-ion monitoring (SIM) during analysis via a triple-quadrupole mass spectrometer and subsequently has been applied ...
  • IM-MS Assessment of Cobalt-Glycan Heterodimers Continuing along our previous work to characterize certain cationized glycans with a variety of metals and with cobalt to enhance UV photon absorption, we are pleased to show our effort to demonstrate the formation of heterodimeric cobalt-glycan adducts in published form. Now appearing as an online-first article in Journal of the American Society for Mass ...
  • Open Source IMS Initiative Update   Following up on previous post, we’ve finally released a major update to the Open Source IMS Initiative.  Appearing now in Hardware X we detail a new modular IMS design that is extremely flexible.  Three of our ASMS 2018 posters feature data from these system and the are proving an invaluable new tool to our research infrastucture.  ...
  • Ion Gates?! Where we’re going we don’t need ion gates! Ion gating remains a critical aspect of drift tube IMS experiment and a range of clever approaches have been used the past.  However, most techniques use a physical grid to modulate the ion beam. In collaboration with Steve Kenyon and Keith Gendreau we’ve adapted a modulated x-ray source to printed circuit board IMS.  Though there ...
  • Congrats to Austen Davis for a Successful Disseration Defense!
  • Recent Publication: Mobility Separation and UVPD of Co-Adducted Tetrasaccharides Ultraviolet photodissociation (UVPD) has had its application directed primarily at biomolecule analysis, but with a common drawback of low fragment abundances. We encountered this same problem with UVPD of two sodiated isomeric glycans, but found a significantly higher fragment yield from the cobalt adducts of those same tetrasaccharides. An additional bonus was that the cobalt ...
  • Animation: Improving Rp by Increasing DT Cell Length Austen has recently assembled an animation demonstrating the effect of increasing drift tube length on resolving power, calculated from peak width contributions from diffusion and gate pulse width. Click the image to view.
  • Recent Publication: Enhanced Mixture Separations of Metal Adducted Tetrasaccharides Using a combination of Fourier transform ion mobility and ion trap mass spectrometry Kelsey demonstrated the degree to which different metal cations were able to enhance isomer separations across a set of tetrasaccharides.  While full resolution was not achieved for the full set of 5 isomers this work demonstrates the current state of the art for ...
  • Open-Source, Modular Approaches to Ion Mobility Spectrometry Outside of an ionization source and a Faraday plate, a drift tube IMS system is fundamentally comprised of 5 primary components: Reaction/Drift Cell Ion Gate Gate Pulsing Electronics Current to Voltage Converter Data Acquisition System (DAQ) Within the IMS research community hardware and DAQ solutions are often custom and rarely replicated exactly. In an effort to address this knowledge and resource gap, ...
  • Fourier Transform Ion Mobility-Ion Trap Mass Spectrometry We are pleased to report the publication of our work outlining the effective coupling of a drift tube IMS system with an ion trap mass spectrometer.  Compared to previous implementations (see our 2005 publication) we have dramatically improved the IMS duty cycle by encoding the mobility information in the frequency domain.  Using this Fourier approach ...
  • Dr. Clowers Recognized for Early Career Achievement In the Spring Semester of 2015, Dr. Clowers was recognized within the College of Arts and Sciences at Washington State University for Early Career Achievement.  The College of Arts and Sciences celebrated achievements in teaching, research, and mentoring at its third annual Appreciation and Recognition Social on April 22, 2015.  Dr. Clowers was one of ...
  • IMS Short Course Worksheet For those that are interested, here is the spreadsheet used in the ASMS 2018 short course.  Thank Dr. Bill Siems if you see him.   Ion Mobility Cal v3
  • Live from Fulmer Hall: Waters G2 We are pleased to announce the unpacking and, more importantly, the successful pump down of the G2.  Combined with a new UPLC unit we anticipate this instrument playing a large role in future metabolomics work in our laboratory. Kudos to Justin Chang from Waters for executing the pump down sequence like a champ.   ...
  • Waters G2 at WSU Unboxing to commence in t-minus 6 days and counting…
  • IMS – Ion Trap Equipped with UV Photofragmentation   In early 2015 the research group is pleased to bring the next generation ion mobility-ion trap system online.  This system is equipped with two ion gates which allows the speed of the IMS to be effectively coupled to the slow scan speeds of traditional ion trapping experiments.  Though not as fast as tradition IMS-TOF configurations, ...
  • We Have Ignition on Ion Engine #1 The Clowers Research Group is now live.  Reporting in are the background ions from ionized air measured using a residual quadrupole gas analyzer and the LeCroy “Panzer” oscilloscope.  These data are to help monitor background gases in the high vacuum chamber (not shown) and provide diagnostic support for gases ionized by the excimer laser (also ...
  • PCB Tools and Gerber Viewer Though seemingly outside the realm of chemistry, electronics lie at the heart of many experimental disciplines as all rely ability to make accurate and reproducible measurements.  An unfortunate byproduct of this requirements is often the reliance on outside sources–just look at your oscilloscope should there be any questions.  In an effort to minimize this reliance ...

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